An alternative analytical method for the therapeutic drug monitoring of irinotecan: toward personalized medicine
نویسندگان
چکیده
B. Posocco, E. Calandra, E. Marangon, S.Crotti, L. Giodini, P. Traldi, G. Toffoli a IRCCS-National Cancer Institute, Experimental and Clinical Pharmacology Division, Department of Translational Research Via Franco Gallini 2, 33081 Aviano, Italy; b ab. NIB, Pediatric Research Institute Città della Speranza, Corso Stati Uniti 4, 35127 Padua, Italy; c IENI CNR, Corso Stati Uniti 4, 35127 Padua, Italy.
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متن کاملEncapsulation of irinotecan in polymeric nanoparticles: Characterization, release kinetic and cytotoxicity evaluation
Objective(s): Irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase I. Recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). Materials and Methods: In this study, irinotecan loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method to...
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تاریخ انتشار 2016